The predictive value of the serum creatinine for the beginning of continuous veno-venous hemofiltration in critically ill patients

Ioana Ghiţescu¹, Judit Eross², V. Ghiţescu³, Sanda-Maria Copotoiu¹

¹ Universitatea de Medicină şi Farmacie, Disciplina A.T.I, Clinica A.T.I. I; Spitalul Clinic Judeţean de Urgenţă Tg. Mureş
² Spitalul Clinic Judeţean de Urgenţă, Clinica A.T.I. I, Tg. Mureş
³ Institutul Medico-Militar, catedra Târgu Mureş

Abstract

Timing for continuous veno-venous hemofiltration (CVVH) in intensive care patients with acute kidney injury (AKI) is uncertain, despite some general accepted criteria.

Objective: Identification of the value of serum creatinine at the beginning of CVVH that influences the 28 days survival.

Material and methods: Retrospective study conducted on 66 critically ill patients with AKI in Tg. Mures general ICU, separated in two groups: group A (31 patients who survived 28 days after admission) and group B (35 non-survivors). We examined for differences between the two groups concerning sex, age, weight, height and SOFA score at the beginning of CVVH. The statistical difference between mean value of the serum creatinine at the beginning of CVVH for both groups was also determined.

Results: There were no statistical differences between group A and B concerning demographic data (p > 0.05) and SOFA score (p = 0.11). The mean value of serum creatinine was 5.42 mg/dl in group A and 7.04 mg/dl in group B, difference that was statistically significant (p = 0.0378).

Conclusions: In the critically ill patients with AKI, initiation of CCVH before the serum creatinine reaches the value of 5.42 mg/dl is associated with a 28 days survival.

Keywords: continuous hemofiltration, timing, serum creatinine, critically ill

Valoarea predictivă a creatininei serice la debutul hemofiltrării continue veno‑venoase la pacientul critic