Triiodothyronine serum level in advanced coronary artery disease

P. Deutsch, M. Gaşpar, Manuela Deutsch, Mioara Cocora, H. Cioloca, Anca Micu, M. Crîsnic
Disciplina Anestezie Terapie Intensivă, Institutul de Boli Cardiovasculare Timişoara

Abstract

In 24 patients with advanced, presurgical coronary artery disease (CAD group, CI) and in 8 patients with no cardiac disease (control group, M) the total triiodothyronine (TT3) and total tetraiodthyronine (TT4) serum concentration were determined. In all patients, the cardiac ejection fraction (EF) was also determined by echography, contrast ventriculography or both. In 5 patients of the CI group the FT4 was determined. The hormone levels were measured in serum by RIA standard method.
In the CI group the TT3 level was lower (x±DS=0.66±0.34ng/ml, n=24) than in the control (M) group (1.09±0,22ng/ml, n=8) (p<0.01). The TT4 level was normal in the CI group (6.39±1.45mg/dl; n=24) and in the control group M (7.72±1.42mg/dl; n=8), although, in 5 patients of the CI group the TT4 level was subnormal (confirmed by FT4 determination). In the CI group there was a significant positive correlation between the TT3 levels and the EF values (Y=3.475x-0.824; r=0.81). The results revealed the presence of a “low T3” syndrome in the CI group. This “low T3” syndrome could express an altered adaptation of the cardiac performance in the patients of the CI group.

Keywords: “low T3” syndrome, advanced coronary artery disease

Triiodotironemia în stadiul avansat-prechirurgical al cardiopatiei ischemice

Jurnalul Român de Anestezie Terapie intensivă 2006 Vol.13 Nr.1, 81-84