The use of pharmacokinetics for optimising postoperative analgesic regimens based on i.v. continuous administration of opioids

Adrian Belîi¹, Julien Pottecher², Julien Huntzinger²
1 Catedra Anesteziologie şi Reanimatologie, Universitatea de Stat de Medicină şi Farmacie «Nicolae Testemiţanu», Republica Moldova; 2 Departamentul Anestezie-Reanimare Chirurgicală B, Spitalul Universitar Angers, Franţa

Abstract

This study comprised a group of 18 cardio-surgical patients. Anesthesia was provided by target controlled infusion (TCI) of propofol and sufentanil. The postoperative analgesic regimens, based on i.v. continuous administration of alfentanil, sufentanil or fentanyl, were pharmacokinetically simulated by Stangraf™ software (Microsoft® & Greenleaf® Inc., Stanford, USA). The interdependence of analgesic regimens with the effects of post anesthetical residues of opioids was also revealed. The aim of this study was to offer the possibility of individualization of analgesic regimens in postoperative periods, but the presented results need to be also clinically proved.

Key words: postoperative analgesia, pharmaco-kinetics simulation, opioid drugs, TCI

Aportul modelării farmacocinetice la optimizarea protocoalelor de analgezie postoperatorie prin perfuzare intravenoasă continuă de opioide

Jurnalul Român de Anestezie Terapie intensivă 2006 Vol.13 Nr.1, 27-31