The perioperative variation of serum triiodothyronine in aortic coronary by-pass grafted patients

P. Deutsch, M. Gaşpar, Manuela Deutsch, D. Săndesc, M. Sintean, Anca Micu, M. Crîsnic
Disciplina Anestezie Terapie Intensivă, Institutul de Boli Cardiovasculare, Facultatea de Medicină Timişoara

Abstract

The perioperative variation of the total triiodothyronine serum concentration (TT3) was determined in 12 patients who had undergone coronary aortic by-pass surgery. All patients had low ejection fraction (<0.40); TT3 and total serum thyroxine (TT4) were determined by RIA methods, preoperatively (Ante) and postoperatively (Post). All patients presented a negative Ante-Post TT3 variation (TT3 Ante,x±DS: 0.80±0.25ng/ml; Post:0.48±0.09ng/ml; p<0.01). TT4 did not have, at the same time, a significant negative variation (TT4 Ante, x±DS: 7.75±1.04mg/dl; Post: 6.99±1.90mg/dl;p>0.20); the corelation between TT3 and TT4 was not significant (y=0.049+0.278; r=0.30). The results showed a “low T3” syndrome installed during the surgical procedure, probably due to a reduced tissue permeability for T4 and/or decreased activity of deiodinaze enzyme.

Key words: coronary aortic by-pass, “lowT3” syndrome

Variaţia perioperatorie a triiodotironinemiei în cursul intervenţiei pe cord deschis

Jurnalul Român de Anestezie Terapie intensivă 2006 Vol.13 Nr.1, 23-26