The efficiency of pre-emptive analgesia with Cox - 2 inhibitors (parecoxib) in laparoscopic cholecystectomy

Dana Tomescu, Anca Prodea, D.Tulbure
Centrul ATI, Institutul Clinic Fundeni Bucureşti

Abstract

The purpose of this study was to evaluate the efficiency of preemptive analgesia with 40 mg parecoxib for postoperative pain therapy after laparoscopic cholecystectomy.
Material and Methods: 62 consenting patients undergoing laparoscopic cholecystectomy were randomly divided into two groups: group A – 32 patients who received 40 mg of parecoxib intravenously before the induction of anaesthesia and group B who received a placebo. The demographic data (age, sex, weight, ASA score) were similar between the two groups, as well as the type of general anaesthesia and the length of the procedure. Assessment of postoperative pain was made by visual analogue scale (VAS) at different times in the immediate postoperative period - 0, 45, 90, 120 minutes.
In group A, the pain scores were constantly under 3, only 6 patients (18.75%) asked for supplemental analgesia, statistically different from group B – all patients (100% ) received opioid analgesia (pain score over 3 at 10). Medium time of stay in the recovery room for patients from group A was 2 hours compared with 3.4 hours for group B.

Conclusion: Pre-emptive analgesia with parecoxib is efficient for postoperative pain therapy and determines an earlier ambulation from the recovery room.

Key words: parecoxib, pre-emptive analgesia, laparoscopic cholecystectomy

Eficienţa analgeziei pre-emptive cu inhibitori selectivi Cox2 (parecoxib) în colecistectomia laparoscopică

Jurnalul Român de Anestezie Terapie intensivă 2005 Vol.12 Nr.2, 129-132