The influence of ethylephrine on some effects of pancuronium and d-tubocurarine. Experimental investigations

Silvia Albu¹, Barbu Cuparencu¹, Vlaicu Şandor²
1) Facultatea de Medicină şi Farmacie, Oradea. 2) Universitatea de Medicină şi Farmacie „Iuliu Haţieganu”, Cluj-Napoca

Abstract

In conscious rats, ethylephrine (0.1–2.5 mg/kg) failed to affect the myorelaxation induced by pancuronium (test of Julou–Courvoisier). Only the highest dose (2.5 mg/kg) prolonged myorelaxation duration significantly. In ethyl-urethane anesthetized rats and guinea-pigs, ethylephrine had only minimal, non significant effects on respiration and on the electrocardiogram modified by the intravenous infusion of d-tubocurarine. From these data it may be concluded that the co-administration of ethylephrine and myorelaxants does not induce harmful interactions.

Key words: ethylephrine, pancuronium, d-tubo-curarine, rats, guinea-pigs

CERCETĂRI EXPERIMENTALE

Influenţa etilefrinei asupra unor efecte ale pancuroniului şi d-tubocurarinei. Cercetări experimentale

Jurnalul Român de Anestezie Terapie intensivă 2005 Vol.12 Nr.1, 141-146