A comparative study of the efficacy of propofol (for induction and maintainance of anesthesia) versus ondansetron in the prevention of postoperative vomiting

Luminita Cīmpeanu1, M. Chioreanu2
1) Compartimentul ATI, Clinica ORL Tārgu Mures 2) Clinica ATI, Spitalul Clinic Judetean Tārgu Mures


In order to evaluate the efficacy of propofol for prophylaxis of postoperative vomiting in children subjected to adenotonsillectomy under general anesthesia, 90 children, aged between 5 and 12 yrs old, were randomly assigned to two groups: group O-ondansetron (receiving 50 μg/kg ondansetron in 10ml saline 0,9% before induction of halothane anaesthesia) and group P-propofol (used for induction and maintenance of anaesthesia). Within the first 6 postoperative hours, the incidence of vomiting in those two groups did not differ significantly. Fewer patients in group P (22,2%) vomited during the 24h period compared to group O (26.6%), the need for rescue antiemetic being significantly lower for that group. Patients in group P had lower sedation scores for the first 6 postoperative hours. There were no differences among the groups in the quality of oral intake.
In conclusion, propofol used to induce and maintain anesthesia seems to be more effective than ondansetron (in halothane anesthesia) in preventing late postoperative vomiting, being also associated with lower request for risk antiemetic and lower sedation scores in the early phase of recovery.

pediatric anaesthesia, vomiting, propofol, ondansetron

Jurnalul Român de Anestezie Terapie intensivă 2003 Vol.10 Nr.2, 125-130

Studiu comparativ al eficienţei propofolului (inducţie şi menţinere anestezică) versus ondansetron, în prevenirea vărsăturilor postoperatorii