Prevention of postoperatory emetic syndrome with ondansetron and dexametazone in patients with middle ear surgery

Luminiţa Câmpeanu1, M. Chiorean2
1) Compartimentul ATI, Clinica ORL 2) Clinica ATI, Spitalul Clinic Judeţean Târgu Mureş


Abstract

Aim. The efficacy of ondansetron in combination with dexamethasone was compared with the efficacy of each drug alone in the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery.

Materials and Methods.
In a randomized, double-blind study, we included 120 patients (85 females) who received ondansetron 4 mg (group O), dexamethasone 8 mg (group D) or ondansetron 4 mg and dexamethasone 8 mg (group OD) i.v. (n = 40 for each group), immediately before induction of anaesthesia.
A standardized general anaesthetic technique was used and the results were recorded in two postanaesthetic periods: 0-3 h and 3-24h.

Results.
A complete response, defined as no PONV and no need for another rescue antiemetic during the first three hours after anaesthesia, was recorded in 82.4%, 50%, and 97.5% of patients who received ondansetron, dexamethasone, and ondansetron + dexamethasone, respectively. The corresponding incidences during the next 21 hours after anaesthesia were 80%, 55% and 97.5% (p<0.05).

Conclusion.
Prophylactic use of combined ondansetron and dexamethasone was more effective than each antiemetic alone for the prevention of PONV after middle-ear surgery.

Key words:
nausea, vomiting, antiemetics, ondansetron, dexamethasone, surgery, otolaryngological

Jurnalul Român de Anestezie Terapie intensivă 2002 Vol.9 Nr.1, 15-20

STUDII CLINICE

Profilaxia sindromului emetic postoperator folosind o combinaţie de ondansetron şi dexametazonă la pacienţi supuşi chirurgiei urechii medii